Nobel Idea :Simulation of Genetic and Environmental impact on human telemere causes of Agin ( Nobel prize by Blackburn 2010)

Operations Simulation of Human Genetic and Environmental Causes of Aging

Warren Huang OSA Global Biotech, Vera Huang, Dept. Molecular and Cell Biology, UC Berkeley, Berkeley, Ca. 94720

Numerous results reported on the genetic and environment impact on life span, mostly indulge in endless elegan and mouse genetics of the evolution of aging and some in human aging disease (cancers, Alzheimer and premature aging in Werner syndrome ). Among the various models systems proposed for causes of aging, the genetics evolutionary approach, the telomerase maintaining the length of telomeres for lasting cell division sounding most promising.

It is well known now, that genetics accounts on for 40 % of aging, while 60 % aging resulted from environmentally in cell damage, gene mutation.

However, steroid and growth hormones play key role in gene regulation, expression, cell growth, division and maintain vitality in human immune systems, organ, tissue, brain and mood at its peak performance through it’s signal transduction pathways and receptors. Its role in aging should have received more attention. As IGF growth hormone, melatonin and steroid hormone (DHEA, Testosterone, estrogen) both of them starting decay In the twenties, it dropped to below 60 % around 60, which cause cancers and Alzheimer, age related diseases.. It is also well known that the hormones self regulatory control have help human adaptive and fighting the fast changing environment, maintaining vitality and quality of life, as the catalysts for refinery, petrochemicals reactors, maintaining products yield and purity. This study call the attention of the conference to pay more attention to the genetic control of hormone, looking into the genes setting the hormone decay . and working closely with the telomeres ( as the telomerase already working closely in the sperm and egg formation), resetting the hormone decay curve, to achieve long, disease free, happy, life.

Presented to Keystone conference of Aging, Feb. 6, 1999, Keystone, Colorado