He has developed, implemented the causes of diseases curing for over 30 drugs production process including antioxidants vitamin E, antibiotics, penicillin, and recombinant DNA approach to Insulin, Hepatitis, monoclonal antibodies, alpha, beta interferon. The results have been presented to global biotech Conferences and  1998 Nov. Int'l anti-cancer conference in Greece and Biotech simulation conference in Lyons, in July.,Keystone  Molecular Cell Biology conference, Colorado, USA, Feb 1999 on Cellular, molecular, genetic approach to aging and cancer prevention  and American Institute of Chemicals Engineers annual meeting, Dallas , Tx USA, Nov. 1999  Drug, Biotech division on Gall and mission oriented biotech research, training

his report consists of over 15 years   research conducted by Dr. Warren Huang, supervising 300 biochemical engineers in the research of the molecular, cellular, genetic approach of the causes, cure, prevention of human body diseases, cancer and aging and the last 5 years extensive review of books, literatures, on the diet, life styles for cancer, aging prevention, cure,.  and joint research with Vera Huang at Molecular Cell Biology Department of Univ of California, Berkeley, and attend numerous Nobel prize winers   ocancer, immune,  aging Prof. Prusner on  Alzheime. Prof. Baltimore on Immune, AIDS, and  Dr. Huang'spersonal experiences with his friends associates over huundred old without cancer.

Over 75 % of cancers can be prevented by proper diets ,  relaxed life quit smoking, drinking,
After spending billions dollars in fighting against the cancer through research into the root causes of cancer at the molecular, genetic and cellular level, we found  75 % of the cancer patients lives could have saved (millions of people died in cancers) just by taking proper diet (low fat, low calories and high fruit, vegetables which can prevent, delay the onset and even stop the cancer spread ) and relaxed happy life, quit smoking. drinking .(stop cell damages caused gene mutation) The rest of cancer are caused by inherited genetic defect and environment pollution. Cancer is no longer a dreadful disease. Yet cancer is still our no. 1 enemy. We know too much about the causes of cancer (etiology),(1-3) we did too little to prevent it. We spend too much money and time in the cancer therapy and animal tests on radio and chemotherapy, which have side effect, with survival rate below 50 %. Use misguided animal test model for human clinical trials. For only 30 % of the patient). It is time for review what went wrong in our national policy and priority on the war against cancer. The answer is simple!. We are fighting in the wrong direction!, and misguided by a few bio-researcher into the endless animal tests. It is time to organize multidisciplinary teams to buildup cancer diet and Chemopreventive information knowledge based human biochemical plants and start serious working on real time simulation of cancer prevention to save 60 % of our cancer patients life with more than 60 % survival rate!

DSA/OSA applied to Real time Simulation and control , preventive maintenance of refinery, petrochemicals, and biotech process performances
The senior author (Warren) pioneered the DSA/OSA (Design and Operations Simulations Analysis) by extended the problem solving decision analysis of Operations Research used by US Aerospace Automatic Guidance. Tracking, Simulation, applying artificial intelligence pattern recognition, adaptive filtering and control to challenge the unknown and impossible task for the Apollo moon landing to Chemical and biotech systems simulation.

Warren extended OSA to molecular, genetic, level human biochemical plant design and operations simulation for causes of cancer and therapy, drugs production process simulations 14 years ago. He directed over 300 senior chemical engineering and biochemicals senior and graduate students to conduct intensive search of global biotech literature, patents (including Chinese herbs)on human cell development, genetic and molecular biology, immunology, cancer and virus caused major diseases and aging, developed drugs process design simulation for 30 biotech drug process, including monoclonal antibodies, interferon's and recombinant DNA applications(4-6)
Human Body Biochemical Plant OSA
Each human body has his unique biochemical plant, immune systems( antibodies and interferon's) genetically inherited(design) and responding differently to the outside environmental impact; pollution's, education's, working and emotional stress(operations). Even the identical twin, will be difference if raised in different environment, as it is compared to two nearby identical designed chemical plant behave differently if it is running under different feed composition, or different climate. .All can be tracked by real time OSA. Process plant central , auxiliary computer control. This approach is applied to the simulation of CNS(central nervous control)Nervous systems control ,PNS (Peripheral nervous systems and hormones self regulatory control and the immune systems antigens patterns recognition antibodies-antigens reactions to a presented steeping for feedback immune self defense, emotional response. while brain memory function compare to computer memory and programs. The computer control systems consists of sensors and signals are sending through currents, as compared to brain receive the sensors signal and send the response through neurons send it through electrolyte neural transmitters in the spinal cord (cable wire) and the cell receptors while the local hormone sending chemical signals through relay and enzyme catalytic reactions amplified by second messengers and protein kinase to regulate the control of cell replication. under genetic preprogrammed DNA/RNA . and interact with the CNS. and plays key role in water, chemical balance and emotional, mood and organ functions. Again, by applying the process plant optimum feedforward set point control can reduce body organ, tissue damage due to offset in feedback control (from genetic repair to water, chemical, molecular balance.
Tracking real causes of cancer:
Excellent review of the mechanism of cancer formation by Ames(1) indicated that Gene mutation, DNA lesion, cell division, ineffective defense systems
Gene Mutation: The real time tracking the real cause of chemicals plant explosion and runaway polymerization is easily applied to the simulations of cancer etiology (to identify the target cell and molecule and mutant genes mechanism in malignant cancer cell formation 30 % caused by tobacco smoking resulted and rodent carcinogens. . Which is well known now due to the mutation of proto-oncogene runaway cell growth in the tumor cell, while its regulatory tumor suppressor gene mutation fail to inhibit the runaway growth ( 50 % of cancer) is similar to the chemical plant free radicals initiated gas phase explosion or liquid phase polymerization (run away reactions).
The cancer gene therapy can be applied effectively by antisense to block the cancer replication or the p53 to suppress and kill the cancer cells . as it did in prevent plant explosion and undesired polymerization by improved design and operating conditions
While the anti-oxidants defensive systems is trying to repair the damages caused by gene mutations caused cancer cell proliferation.

How is DSA/OSA applied to tracking causes of Aging, Cancer and Chemopreventive programs Development of cancer Chemopreventive biochemical plant information knowledge base
These molecular, genetic and cellular level DSA/OSA of human cancer Chemopreventive program is supported by good human cancer Chemopreventive biochemical plant information knowledge base. Which developed out of extensive literature search on the molecular, cellular, genetic caused of various cancers and matched by extensive knowledge of diets(fruit, vegetables, nutrition supplements) chemicals related to various stages of cancer prevention. ( before the onset of tumor, cancer cell and metastatic spread. And the full range animal and human clinical trial data
A good Chemopreventive program must include quit smoking to eliminate 30 % of cancer occurrence., while the diet
Must include low fat, low calorie and fruits, vegetables and vitamins, minerals which contains chemicals fight against various stages of cancers:
A. Prevent normal cell become tumor or delay on set of cancer cell formation.
Antioxidants: Vitamin A, E, C, Beta-carotene rich in most soybean, carrots, tomatoes and green vegetables and grape, oranges, fruits for remove free radicals, protect normal cell to form cancer cells stops or delay the onset of tumor,cancer formation.
.Minerals, Vitamins: Calcium,, for membrane protection, selenium for catalyze glutathione tripeptide remove peroxide toxin, folic acid for DNA synthesis DNA avoid misincorporation of Uracil resulted DNA lesion, Zinc for boost immune systems
Amino Acids: Arganine for boost immune defense, Lysine for tissue repair, antibody.
B Block tumor or cancer cell formation
Phytochemicals block the tumor or cancer cell by cutting it's blood supply or prevent it's growth can be found in soybeans, like genisten, and it's protease inhibitors, block estrogen receptors to prevent breast cancers and cruciferous vegetables as broccoli, cabbage, cauliflower , and
C. Prevent Cancer spreads:
Artificial tripeptide (arginine,-glycine-aspartic acid binding to cell receptors block cancers invasion.
While green tea's epigallocationtechin protect all stages of cancers through inhibit angiogenesis,- celery rich in dithiolthiones, organosulfur compounds  and beets lignan , barley cut  cancer blood vessel blood supply, block cancers growth  the formation new blood vessel.
Development of cancer Chemopreventive program. real time simulation:
Tracking, simulating each individual diet chemicals dosage, schedule impact on each cancer curing performance.
To setup Chemopreventive diet program for reach individual cancer prevention. To reduce or hopefully eventually eliminate animal tests and clinical trials.
The authors started OSA/DSA to Chemopreventive systems simulations 14 years ago, have personally administered combined chemotherapy and chempreventive programs, tracking the cocktail blend of up to 30 components of antioxidants (vitamin A, B, C, E, selenium, etc)vegetables extract(broccoli) green ,tea , grape seed, pumpkin seed extract for inhibit tumors, folic acid for one years program . These cocktail program has boosted the immune systems maintain healthy, happier life and shrinke, eliminated bleeding tumor in 6 months(at the onset of 10 year old mole)
References:
Huang,W." Improve Process by OSA",-May 1980, Hydrocarbon Processing
Huang,W." OSA/DSA Approach to Biotech and Recombinant DNA",- int'l Biotech Conference, Sept. 1985, Singapore
Huang,W" OSA/DSA Approach to Chemicals and Biotech Reactors", to ACHEMA, Sept. 1991, Frankfurt, Germany.
Huang,W, Huang, V." Human Body Biochemical Plant Design, Operations Simulation"- Biotech Simulation Conf, July, 1998, Lyon,France
Huang,W, Huang, V"Aging, Disease, Therapy Operations Simulation",- Biotech Simulation Conf, July, 1998, Lyon,France

presented to Int'l anticancer conference Oct. 21-25, 1998 Greece

Contact Information E-mail :  whuang@osawh.com  Fax : 1-510-524-4484(  San Francisco, USA)