Molecular, Cellular, Genetic Approach to Real Time Simulation of Cancer Causes , Cures and preventive Program

Vera Huang, Molecular, Cell Biology Dept , University of California , Berkeley, Ca. USA
Email verah@uclink4.berkeley.edu
Warren Huang OSA Int'l Operations Analysis, San Francisco ,Ca Fax: 1-510-524-4484
(to who should be addressed to) e-mail Add. Whuang@osawh.com/   whuang3928@aol.com

OSA biotech simulation pioneer Dr. Warren Huang extended his 32 years real time refinery, petrochemical, polymer, pharmaceutical process plant simulation experiences 14 years ago, directed 300 Biochemical engineers senior, graduate students to molecular, cellular, genetics approach to tracking, simulation of human body biochemical plant design, operations simulation, tracking the real causes of diseases, aging, and prevention through chemo-preventive, gene therapy, hormone replacement therapy to minimize time wasted in random animal tests and human clinical trial, speedup the R&D into commercialization process.

He has developed, implemented the causes of diseases curing for over 30 drugs production process including antioxidants vitamin E, antibiotics, penicillin, and recombinant DNA approach to Insulin, Hepatitis, monoclonal antibodies, alpha, beta interferon. The results have been presented to global biotech Conferences and  1998 Nov. Int'l anti-cancer conference in Greece and Biotech simulation conference in Lyons, in July Keystone  Molecular Cell Biology conference, Colorado, USA, Feb 1999 on Cellular, molecular, genetic approach to aging and cancer prevention  and American Institute of Chemicals Engineers annual meeting, Dallas , Tx USA, Nov. 1999  Drug, Biotech division on Gall and mission oriented biotech research, training

This report consists of over 15 years   research conducted by Dr. Warren Huang, supervising 300 biochemical engineers in the research of the molecular, cellular, genetic approach of the causes, cure, prevention of human body diseases, cancer and aging and the last 5 years extensive review of books, literatures, on the diet, life styles for cancer, aging prevention, cure,.  and joint research with Vera Huang at Molecular Cell Biology Department of Univ of California, Berkeley, and attend numerous Nobel prize winners   cancer, immune,  aging Prof. Prusner on  Alzheime. Prof. Baltimore on Immune, AIDS, and  Dr. Huang's personal experiences with his friends associates over hundred old without cancer.
Over 75 % of cancers can be prevented by proper diets ,  relaxed life quit smoking, drinking,

After spending billions dollars in fighting against the cancer through research into the root causes of cancer at the molecular, genetic and cellular level, we found  75 % of the cancer patients lives could have saved (millions of people died in cancers) just by taking proper diet (low fat, low calories and high fruit, vegetables which can prevent, delay the onset and even stop the cancer spread ) andrelaxed happy life, quit smoking. drinking.(stop cell damages caused gene mutation) The rest of cancer are caused by inherited genetic defect and environment pollution. Cancer is no longer a dreadful disease. Yet cancer is still our no. 1 enemy. We know too much about the causes of cancer(etiology),(1-3) we did too little to prevent it. We spend too much money and time in the cancer therapy and animal tests on radio and chemotherapy, which have side effect, with survival rate below 50 %. Use misguided animal test model for human clinical trials. For only 30 % of the patient). It is time for review what went wrong in our national policy and priority on the war against cancer. The answer is simple!. We are fighting in the wrong direction!, and misguided by a few bio-researcher into the endless animal tests. It is time to organize multidisciplinary teams to buildup cancer diet and Chemopreventive information knowledge based human biochemical plants and start serious working on real time simulation of cancer prevention to save 60 % of our cancer patients life with more than 60 % survival rate! .

What is cancer:
The biology of cancer  start human cell  fail  recognize and suppres   tumor, cancer cell  grow, and spread to  damage normal function in tissue, organ to repair, replicte the damaged cell due to genetic mutation, environmental oxidativc damaging on our DNA, fail to perform necessay sigal transduction to maintan necessary function

Why people have cancer :
Cancer is causesed by abnormal cell growth, into tumor, and develpe into cancer cell, due to genetic inherited gene mutation, (only 10 %), and environmental pollution, (chemical polution, smoking, alcohol) diet caused carcinogene (cancer causing chemicla),  are the major causes for such cancer causing chemical attack related gene mutation and cell damage

What ages having cancer:

It takes 5 to 10 years to develope breast, uterus  tumor, started at age 15 for female till 55 caused by high level of estrogen (cancer growth factor), genetic inherited cancer  can start as early as 22, under environment stimulation, drinking, smoking, diet, air pollutiom,  and emotional depression, tension,  maintain high esrogen level for pregancy requirement, decay fast after  menopause), while male estrogen level decay since age 25 till 65,cancer develope after 22 for genetic inherited, while running cancer risks till 65 due to emvironemntal impact stated above

Whar is the impact of  genetic inheritation and environmental causes on cancer
It is not horrible if you are geneticaly inherited  cancer from your parent, you only have 10 % more chances than other in getting,  cancer you can pospone, or prevent 90 % of the  cancer by  the life style and diet stated here

Why drinking and smoking causing cancer:
Drinking alcohol will lead to liver cell damage, tumor anc cancer cell growth, while smoking in nicotine and and charcoal, fried food, benzene  pollution , lead to pyrobanzene formation, lead to lung cell and DNA damage, tumor, cancer formation.

Can our body cell repair and fight cancer cell?
Yes. Our body l growth and death, p53 , a protein, can suppress tumor growth, while oncogenene promote cell growth. The tumor growth will be out of control if p53 is mutated (genetic inherited or damaged by emotional anxiety, suppression, anger

How can we postpone, prevent tumor formation:
it has been found that various antioxidant like vitamin C, E,beta carotene, selenoid, can prevent the formation due to cross-linking, tumor formation, while protein chamicals in tomoto(lycopene) prevent, delay the onset of prostate cancer, water melon,  red ruby grapefruit are good for breast, uterus cancer formation, grape seed, green tea have been known for cancer prevention too

Can we stop the cancer cell spread and shrink the tumor:
It is well known that Broccoli, Cabbage, carflowers , celery, beets can cut the cancer cell blood supply to shrink tumor, cancer cell. While Lincheehas been used with some sucess to achieve the same purposes

This diet will kept daily calrie below 1500 and provide necessay vegetable, animal protein, vitamins for health maintainence  immune support for cancer fight

This life style and living philosophy help you to live cancer free  happy long life:

Happiness start from your positive thinking inside you , not the wealth and friends surround you:
Goal, mission, performances oriented life, always have dreams, and setting goal, mission, performance
to achieve it. Dr. Huang's thesis adviser a world renowned chemical engieeering prof , self made billionaire,
live ed very simple life, no entaintaing, (No TV radio in the house, dedicated to his teaching and research work till he died at 102 without cancer . We worked till midnight for our paper sfor publication and encyclopedia. last time I met him at his 90 birthday in Washington DC, We were invited to speak to American Institute of Chemicla Engineers Diamoond Jubilee meeting, he said, he enjoyed talking to 600 Beijin University students
people at 25 have their dreams, as they getting older, they are frustrated, withdraw, or retired, with any goal, dreams, they ages, suffered, heart attack, cancer..Anger, depression are the no 1 enemy in cancerand aging(lead to p53 mutation, cell damage (Tumor suppresor )
maintain physical and mentally active, watc you sit position,, frequent streching, do not sit and read, watch TV more than one hour without rest, stretching ( Dr Huang does not wear eye glass)

Tracking real causes of cancer:
Excellent review of the mechanism of cancer formation by Ames(1) indicated that Gene mutation, DNA lesion, cell division, ineffective defense systems
Gene Mutation: The real time tracking the real cause of chemicals plant explosion and runaway polymerization is easily applied to the simulations of cancer etiology (to identify the target cell and molecule and mutant genes mechanism in malignant cancer cell formation 30 % caused by tobacco smoking resulted and rodent carcinogens. . Which is well known now due to the mutation of proto-oncogene runaway cell growth in the tumor cell, while its regulatory tumor suppressor gene mutation fail to inhibit the runaway growth ( 50 % of cancer) is similar to the chemical plant free radicals initiated gas phase explosion or liquid phase polymerization (run away reactions).
The cancer gene therapy can be applied effectively by antisense to block the cancer replication or the p53 to suppress and kill the cancer cells . as it did in prevent plant explosion and undesired polymerization by improved design and operating conditions
While the anti-oxidants defensive systems is trying to repair the damages caused by gene mutations caused cancer cell proliferation.

How is DSA/OSA applied to tracking causes of Aging, Cancer and Chemopreventive programs Development of cancer Chemopreventive biochemical plant information knowledge base
These molecular, genetic and cellular level DSA/OSA of human cancer Chemopreventive program is supported by good human cancer Chemopreventive biochemical plant information knowledge base. Which developed out of extensive literature search on the molecular, cellular, genetic caused of various cancers and matched by extensive knowledge of diets(fruit, vegetables, nutrition supplements) chemicals related to various stages of cancer prevention. ( before the onset of tumor, cancer cell and metastatic spread. And the full range animal and human clinical trial data
A good Chemopreventive program must include quit smoking to eliminate 30 % of cancer occurrence., while the diet
Must include low fat, low calorie and fruits, vegetables and vitamins, minerals which contains chemicals fight against various stages of cancers:
A. Prevent normal cell become tumor or delay on set of cancer cell formation.
Antioxidants: Vitamin A, E, C, Beta-carotene rich in most soybean, carrots, tomatoes and green vegetables and grape, oranges, fruits for remove free radicals, protect normal cell to form cancer cells stops or delay the onset of tumor,cancer formation.
.Minerals, Vitamins: Calcium,, for membrane protection, selenium for catalyze glutathione tripeptide remove peroxide toxin, folic acid for DNA synthesis DNA avoid misincorporation of Uracil resulted DNA lesion, Zinc for boost immune systems
Amino Acids: Arganine for boost immune defense, Lysine for tissue repair, antibody.
B Block tumor or cancer cell formation
Phytochemicals block the tumor or cancer cell by cutting it's blood supply or prevent it's growth can be found in soybeans, like genisten, and it's protease inhibitors, block estrogen receptors to prevent breast cancers and cruciferous vegetables as broccoli, cabbage, cauliflower ,rich in dithiolthiones, organosulfur compounds block cancers growth
C. Prevent Cancer spreads:
Artificial tripeptide (arginine,-glycine-aspartic acid binding to cell receptors block cancers invasion.
While green tea's epigallocationtechin protect all stages of cancers through inhibit angiogenesis,- the formation new blood vessel.
Development of cancer Chemopreventive program. real time simulation:
Tracking, simulating each individual diet chemicals dosage, schedule impact on each cancer curing performance.
To setup Chemopreventive diet program for reach individual cancer prevention. To reduce or hopefully eventually eliminate animal tests and clinical trials.
The authors started OSA/DSA to Chemopreventive systems simulations 14 years ago, have personally administered combined chemotherapy and chempreventive programs, tracking the cocktail blend of up to 30 components of antioxidants (vitamin A, B, C, E, selenium, etc)vegetables extract(broccoli) green ,tea extract for inhibit tumors, folic acid for one years program . These cocktail program has boosted the immune systems maintain healthy, happier life and shrinked , eliminated bleeding tumor in 6 months(at the onset of 10 year old mole)
References:
Huang,W." Improve Process by OSA",-May 1980, Hydrocarbon Processing
Huang,W." OSA/DSA Approach to Biotech and Recombinant DNA",- int'l Biotech Conference, Sept. 1985, Singapore
Huang,W" OSA/DSA Approach to Chemicals and Biotech Reactors", to ACHEMA, Sept. 1991, Frankfurt, Germany.
Huang,W, Huang, V." Human Body Biochemical Plant Design, Operations Simulation"- Biotech Simulation Conf, July, 1998, Lyon,France
Huang,W, Huang, V"Aging, Disease, Therapy Operations Simulation",- Biotech Simulation Conf, July, 1998, Lyon,France

presented to Int'l anticancer conference Oct. 21-25, 1998 Greece

Contact Information E-mail :  whuang@osawh.com  Fax : 1-510-524-4484(  San Francisco, USA)

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